Publications

In Vivo Models for Prostate Cancer Research

Adamiecki, R.; Hryniewicz-Jankowska, A.; Ortiz, M.A.; Li, X.; Porter-Hansen, B.A.; Nsouli, I.; Bratslavsky, G.; Kotula, L

Cancers (2022). https://doi.org/10.3390/cancers14215321

PMID: 36358740

https://doi.org/10.3390/cancers14215321

ABI1-based expression signature predicts breast cancer metastasis and survival

Regua, A., Papp, C., Grageda, A., Porter, B., Caza, T., Bichindaritz, I., Krendel, M., Sivapiragasam, A., Bratslavsky, G., Kuznetsov, V.A. and Kotula, L.

Molecular Oncology (2022). https://doi.org/10.1002/1878-0261.13175

PMID: 34967509
https://febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13175

Novel Target Opportunities in Non-Metastatic Castrate Resistant Prostate Cancer

Gleicher, S.; Porter, B.A.; Nath, D.; Li, G.; Khanna, R.; Goldberg, H.; Kortylewski, M.; Bratslavsky, G.; Kotula, L

Cancers, 13, 2426 (2021). https://doi.org/10.3390/cancers13102426

PMID: 34067832

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157020/

Src family kinases, adaptor proteins and the actin cytoskeleton in epithelial-to-mesenchymal transition

Ortiz, M.A., Mikhailova, T., Li, X., Porter, B.A., Bah, A., Kotula, L.

Cell Commun Signal 19, 67 (2021). https://doi.org/10.1186/s12964-021-00750-x

PMID: 34193161

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247114/

The physiological role of Wnt pathway in normal development and cancer

Li, X., Ortiz MA., Kotula L.

Experimental Biology and Medicine 2020; 0: 1–16. DOI: 10.1177/1535370220901683

PMID: 31996036

https://www.ncbi.nlm.nih.gov/pubmed/31996036

Structure and Function of the Nuclear Receptor Superfamily and Current Targeted Therapies of Prostate Cancer.

Porter BA, Ortiz MA, Bratslavsky G, Kotula L.

Cancers (Basel). 2019 Nov 23;11(12). pii: E1852. doi: 10.3390/cancers11121852. Review.

PMID: 31771198

https://www.ncbi.nlm.nih.gov/pubmed/31771198

Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling

Nath D, Li X, Mondragon C, Post D, Chen M, White JR, Hryniewicz-Jankowska A, Caza T, Kuznetsov VA, Hehnly H, Jamaspishvili T, Berman DM, Zhang F, Kung SHY, Fazli L, Gleave ME, Bratslavsky G, Pandolfi PP, Kotula L.

Cell Commun Signal. 2019 Sep 18;17(1):120. doi: 10.1186/s12964-019-0410-y.

PMID: 31530281

https://www.ncbi.nlm.nih.gov/pubmed/31530281

Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer.

Kretschmer A, Zhang F, Somasekharan SP, Tse C, Leachman L, Gleave A, Li B, Asmaro I, Huang T, Kotula L, Sorensen PH, Gleave ME.

Sci Rep. 2019 May 24;9(1):7826. doi: 10.1038/s41598-019-44346-5.

PMID: 31127190

https://www.ncbi.nlm.nih.gov/pubmed/31127190

Dorsal ruffles enhance activation of Akt by growth factors.

Yoshida S, Pacitto R, Sesi C, Kotula L, Swanson JA.

J Cell Sci. 2018 Nov 16;131(22). pii: jcs220517. doi: 10.1242/jcs.220517.

PMID: 30333140

https://www.ncbi.nlm.nih.gov/pubmed/30333140

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models.

Nath D, White JR, Bratslavsky G, Kotula L.

J Vis Exp. 2018 Sep 18;(139). doi: 10.3791/58397.

PMID: 30295668

https://www.ncbi.nlm.nih.gov/pubmed/30295668

Bone marrow-specific loss of ABI1 induces myeloproliferative neoplasm with features resembling human myelofibrosis.

Chorzalska A, Morgan J, Ahsan N, Treaba DO, Olszewski AJ, Petersen M, Kingston N, Cheng Y, Lombardo K, Schorl C, Yu X, Zini R, Pacilli A, Tepper A, Coburn J, Hryniewicz-Jankowska A, Zhao TC, Oancea E, Reagan JL, Liang O, Kotula L, Quesenberry PJ, Gruppuso PA, Manfredini R, Vannucchi AM, Dubielecka PM.

Blood. 2018 Nov 8;132(19):2053-2066. doi: 10.1182/blood-2018-05-848408. Epub 2018 Sep 13.

PMID: 30213875

https://www.ncbi.nlm.nih.gov/pubmed/30213875

Gravin regulates centrosome function through PLK1.

Colicino EG, Garrastegui AM, Freshour J, Santra P, Post DE, Kotula L, Hehnly H.

Mol Biol Cell. 2018 Mar 1;29(5):532-541. doi: 10.1091/mbc.E17-08-0524. Epub 2017 Dec 27.

PMID: 29282278

https://www.ncbi.nlm.nih.gov/pubmed/29282278

Novel Concept and Method of Endoscopic Urethral Stricture Treatment Using Liquid Buccal Mucosal Graft.

Nikolavsky D, Manwaring J, Bratslavsky G, Caza T, Landas S, Hryniewicz-Jankowska A, Kotula L.

J Urol. 2016 Dec;196(6):1788-1795. doi: 10.1016/j.juro.2016.05.028. Epub 2016 May 10.

PMID:27177425

https://www.ncbi.nlm.nih.gov/pubmed/27177425

Implications of High Rates of Metastatic Prostate Cancer in BRCA2 Mutation Carriers.

Gleicher S, Kauffman EC, Kotula L, Bratslavsky G, Vourganti S.

Prostate. 2016 Sep;76(13):1135-45. doi: 10.1002/pros.23204. Epub 2016 May 26. Review.

PMID: 27225637

https://www.ncbi.nlm.nih.gov/pubmed/27225637

Reciprocal regulation of Abl kinase by Crk Y251 and Abi1 controls invasive phenotypes in glioblastoma.

Kumar S, Lu B, Dixit U, Hossain S, Liu Y, Li J, Hornbeck P, Zheng W, Sowalsky AG, Kotula L, Birge RB.

Oncotarget. 2015 Nov 10;6(35):37792-807. doi: 10.18632/oncotarget.6096.

PMID: 26473374

https://www.ncbi.nlm.nih.gov/pubmed/26473374

Loss of Wave1 gene defines a subtype of lethal prostate cancer.

Sowalsky AG, Sager R, Schaefer RJ, Bratslavsky G, Pandolfi PP, Balk SP, Kotula L.

Oncotarget. 2015 May 20;6(14):12383-91.

PMID: 25906751

https://www.ncbi.nlm.nih.gov/pubmed/25906751

Defining the radiobiology of prostate cancer progression: An important question in translational prostate cancer research.

Vourganti S, Donaldson J, Johnson L, Turkbey B, Bratslavsky G, Kotula L.

Exp Biol Med (Maywood). 2014 Jul;239(7):805-812. Epub 2014 May 30.

PMID: 24879423

https://www.ncbi.nlm.nih.gov/pubmed/24879423

Crk and ABI1: binary molecular switches that regulate abl tyrosine kinase and signaling to the cytoskeleton.

Hossain S, Dubielecka PM, Sikorski AF, Birge RB, Kotula L.

Genes Cancer. 2012 May;3(5-6):402-13. doi: 10.1177/1947601912460051.

PMID: 23226578

https://www.ncbi.nlm.nih.gov/pubmed/23226578

The emerging role of protein kinase Cθ in cytoskeletal signaling.

Michalczyk I, Sikorski AF, Kotula L, Junghans RP, Dubielecka PM.

J Leukoc Biol. 2013 Mar;93(3):319-27. doi: 10.1189/jlb.0812371. Epub 2012 Nov 27. Review.

PMID: 23192428

https://www.ncbi.nlm.nih.gov/pubmed/23192428

Abi1, a critical molecule coordinating actin cytoskeleton reorganization with PI-3 kinase and growth signaling.

Kotula L.

FEBS Lett. 2012 Aug 14;586(17):2790-4. doi: 10.1016/j.febslet.2012.05.015. Epub 2012 May 19. Review.

PMID: 22617151

https://www.ncbi.nlm.nih.gov/pubmed/22617151

Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice.

Xiong X, Chorzalska A, Dubielecka PM, White JR, Vedvyas Y, Hedvat CV, Haimovitz-Friedman A, Koutcher JA, Reimand J, Bader GD, Sawicki JA, Kotula L.

Oncogenesis. 2012 Sep 3;1:e26. doi: 10.1038/oncsis.2012.28.

PMID: 23552839

https://www.ncbi.nlm.nih.gov/pubmed/23552839

Essential role for Abi1 in embryonic survival and WAVE2 complex integrity.

Dubielecka PM, Ladwein KI, Xiong X, Migeotte I, Chorzalska A, Anderson KV, Sawicki JA, Rottner K, Stradal TE, Kotula L.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7022-7. doi: 10.1073/pnas.1016811108. Epub 2011 Apr 11.

PMID: 21482783

https://www.ncbi.nlm.nih.gov/pubmed/21482783

Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells.

Dubielecka PM, Machida K, Xiong X, Hossain S, Ogiue-Ikeda M, Carrera AC, Mayer BJ, Kotula L.

FEBS Lett. 2010 Aug 4;584(15):3279-86. doi: 10.1016/j.febslet.2010.06.029. Epub 2010 Jun 23.

PMID: 20598684

https://www.ncbi.nlm.nih.gov/pubmed/20598684

Differential regulation of macropinocytosis by Abi1/Hssh3bp1 isoforms.

Dubielecka PM, Cui P, Xiong X, Hossain S, Heck S, Angelov L, Kotula L.

PLoS One. 2010 May 10;5(5):e10430. doi: 10.1371/journal.pone.0010430.

PMID: 20479892

https://www.ncbi.nlm.nih.gov/pubmed/20479892

Interaction of HIV-1 gp41 core with NPF motif in Epsin: implication in endocytosis of HIV.

Huang JH, Qi Z, Wu F, Kotula L, Jiang S, Chen YH.

J Biol Chem. 2008 May 30;283(22):14994-5002. doi: 10.1074/jbc.M800525200. Epub 2008 Mar 28.

PMID: 18375383

https://www.ncbi.nlm.nih.gov/pubmed/18375383

Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1.

Xiong X, Cui P, Hossain S, Xu R, Warner B, Guo X, An X, Debnath AK, Cowburn D, Kotula L.

Biochim Biophys Acta. 2008 May;1783(5):737-47. doi: 10.1016/j.bbamcr.2008.01.028. Epub 2008 Feb 15.

PMID:18328268

https://www.ncbi.nlm.nih.gov/pubmed/18328268

Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.

Tsujio I, Zaidi T, Xu J, Kotula L, Grundke-Iqbal I, Iqbal K.

FEBS Lett. 2005 Jan 17;579(2):363-72.

PMID:15642345

https://www.ncbi.nlm.nih.gov/pubmed/15642345

Structural analysis of the alpha N-terminal region of erythroid and nonerythroid spectrins by small-angle X-ray scattering.

Mehboob S, Jacob J, May M, Kotula L, Thiyagarajan P, Johnson ME, Fung LW.

Biochemistry. 2003 Dec 16;42(49):14702-10.

PMID:14661984

https://www.ncbi.nlm.nih.gov/pubmed/14661984

Human Spectrin SRC Homology 3 Domain Binding Protein 1 (HSSH3BP1) is a Potential Regulator of Macropinocytosis and a Putative Tumor Suppressor.

Kotula L, Xu J, Ziemnicka D.

Cell Mol Biol Lett. 2001;6(2):213-214. No abstract available.

PMID: 11544666

https://www.ncbi.nlm.nih.gov/pubmed/11544666

Loss of expression of human spectrin src homology domain binding protein 1 is associated with 10p loss in human prostatic adenocarcinoma.

Macoska JA, Xu J, Ziemnicka D, Schwab TS, Rubin MA, Kotula L.

Neoplasia. 2001 Mar-Apr;3(2):99-104.

PMID: 11420744

https://www.ncbi.nlm.nih.gov/pubmed/11420744

Monoclonal antibodies to alphaI spectrin Src homology 3 domain associate with macropinocytic vesicles in nonerythroid cells.

Xu J, Ziemnicka D, Scalia J, Kotula L.

Brain Res. 2001 Apr 13;898(1):171-7.

PMID:11292462

https://www.ncbi.nlm.nih.gov/pubmed/11292462

Human spectrin Src homology 3 domain binding protein 1 regulates macropinocytosis in NIH 3T3 cells.

Xu J, Ziemnicka D, Merz GS, Kotula L.

J Cell Sci. 2000 Nov;113 Pt 21:3805-14.

PMID:11034908

https://www.ncbi.nlm.nih.gov/pubmed/11034908

Two distinct mechanisms for regulation of nonmuscle myosin assembly via the heavy chain: phosphorylation for MIIB and mts 1 binding for MIIA.

Murakami N, Kotula L, Hwang YW.

Biochemistry. 2000 Sep 19;39(37):11441-51.

PMID:10985790

https://www.ncbi.nlm.nih.gov/pubmed/10985790

Altered binding of mutated presenilin with cytoskeleton-interacting proteins.

Johnsingh AA, Johnston JM, Merz G, Xu J, Kotula L, Jacobsen JS, Tezapsidis N.

FEBS Lett. 2000 Jan 7;465(1):53-8.

PMID:10620705

https://www.ncbi.nlm.nih.gov/pubmed/10620705

Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton.

Ziemnicka-Kotula D, Xu J, Gu H, Potempska A, Kim KS, Jenkins EC, Trenkner E, Kotula L.

J Biol Chem. 1998 May 29;273(22):13681-92.

PMID: 9593709

https://www.ncbi.nlm.nih.gov/pubmed/9593709

Solution conformations of a peptide containing the cytoplasmic domain sequence of the beta amyloid precursor protein.

Kroenke CD, Ziemnicka-Kotula D, Xu J, Kotula L, Palmer AG 3rd.

Biochemistry. 1997 Jul 1;36(26):8145-52.

PMID: 9201963

https://www.ncbi.nlm.nih.gov/pubmed/9201963

Physical properties of a single-motif erythrocyte spectrin peptide: a highly stable independently folding unit.

DeSilva TM, Harper SL, Kotula L, Hensley P, Curtis PJ, Otvos L Jr, Speicher DW.

Biochemistry. 1997 Apr 1;36(13):3991-7.

PMID: 9092829

https://www.ncbi.nlm.nih.gov/pubmed/9092829

Molecular basis and haplotyping of the alphaII domain polymorphisms of spectrin: application to the study of hereditary elliptocytosis and pyropoikilocytosis.

Gallagher PG, Kotula L, Wang Y, Marchesi SL, Curtis PJ, Speicher DW, Forget BG.

Am J Hum Genet. 1996 Aug;59(2):351-9.

PMID: 8755921

https://www.ncbi.nlm.nih.gov/pubmed/8755921

Mapping the human erythrocyte beta-spectrin dimer initiation site using recombinant peptides and correlation of its phasing with the alpha-actinin dimer site.

Ursitti JA, Kotula L, DeSilva TM, Curtis PJ, Speicher DW.

J Biol Chem. 1996 Mar 22;271(12):6636-44.

PMID: 8636080

https://www.ncbi.nlm.nih.gov/pubmed/8636080

Review. David Oppenheimer Memorial Lecture 1995: Some neuropathological aspects of Alzheimer's disease and its relevance to other disciplines.

Wisniewski HM, Wegiel J, Kotula L.

Neuropathol Appl Neurobiol. 1996 Feb;22(1):3-11. Review.

PMID: 8866776

https://www.ncbi.nlm.nih.gov/pubmed/8866776

New hopes arise with the transgenic model for Alzheimer's disease.

Kotula L, Wisniewski HM.

Neurobiol Aging. 1995 Jul-Aug;16(4):701-3. No abstract available.

PMID: 8544922

https://www.ncbi.nlm.nih.gov/pubmed/8544922

Functional characterization of recombinant human red cell alpha-spectrin polypeptides containing the tetramer binding site.

Kotula L, DeSilva TM, Speicher DW, Curtis PJ.

J Biol Chem. 1993 Jul 15;268(20):14788-93.

PMID: 8325856

https://www.ncbi.nlm.nih.gov/pubmed/8325856

Low expression allele alpha LELY of red cell spectrin is associated with mutations in exon 40 (alpha V/41 polymorphism) and intron 45 and with partial skipping of exon 46.

Wilmotte R, Maréchal J, Morlé L, Baklouti F, Philippe N, Kastally R, Kotula L, Delaunay J, Alloisio N.

J Clin Invest. 1993 May;91(5):2091-6.

PMID: 8486776

https://www.ncbi.nlm.nih.gov/pubmed/8486776

Evaluation of foreign gene codon optimization in yeast: expression of a mouse IG kappa chain.

Kotula L, Curtis PJ.

Biotechnology (N Y). 1991 Dec;9(12):1386-9.

PMID:1367771

https://www.ncbi.nlm.nih.gov/pubmed/1367771

The exon-intron organization of the human erythrocyte alpha-spectrin gene.

Kotula L, Laury-Kleintop LD, Showe L, Sahr K, Linnenbach AJ, Forget B, Curtis PJ.

Genomics. 1991 Jan;9(1):131-40.

PMID:1672285

https://www.ncbi.nlm.nih.gov/pubmed/1672285

The complete cDNA and polypeptide sequences of human erythroid alpha-spectrin.

Sahr KE, Laurila P, Kotula L, Scarpa AL, Coupal E, Leto TL, Linnenbach AJ, Winkelmann JC, Speicher DW, Marchesi VT, et al.

J Biol Chem. 1990 Mar 15;265(8):4434-43.

PMID:1689726

https://www.ncbi.nlm.nih.gov/pubmed/1689726

Xba I polymorphisms in the 5' region of human erythrocyte alpha spectrin gene (Spna).

Kotula L, Curtis P.

Nucleic Acids Res. 1988 Nov 25;16(22):10950. No abstract available.

PMID: 2905046

https://www.ncbi.nlm.nih.gov/pubmed/2905046